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标题: 肿瘤大小显着减小肺 [打印本页]

作者: mdhacibul260@gm    时间: 2023-9-21 19:30     标题: 肿瘤大小显着减小肺

癌扩增。这一证据表明作为控制吸烟者鳞状细胞肺癌的候选疗法。抽象的肺癌仍然是发达国家癌症相关死亡的主要原因之一。尽管具有突变或融合的肺腺癌分别对表皮生长因子受体和间变性淋巴瘤激酶抑制的治疗有反应,但鳞状细胞肺癌目前 缺乏治疗上可利用的基因改变。我们对个肺癌样本进 行了系统性搜索,寻找适合治疗的基因改变,然后进行了高分辨率基因拷贝数分析。我们发现鳞状细胞肺癌中存在频繁且局部的成纤维细

胞生长因子受体扩增。),但在其他肺癌亚型中没有,并且通过荧光原位杂交,证实了鳞状细胞肺癌样本的独立队列中存在扩增(占病例的)。通过在大量n肺癌细胞系中使用抑制剂进行细胞筛选,我们证明该化合物特别是在那些哥斯达黎加电话号码表哥斯达黎加电话号码表
携带扩增的肺癌细胞中抑制生长并诱导细胞凋亡。我们通过敲低和抗性等位 基因的异位表达来验证扩增细胞系的依赖性,该等位 基因拯救了来自介导的细胞毒性的扩增细胞。最后,我们发现用小分子抑制可导致体内肿瘤显着缩小。



因此,局灶性扩增在鳞状细胞肺癌中很常见,并且与肿瘤生长和存活相关,这表明抑制剂可能是这组患者的可行治疗选择。体细胞突变影响肺腺癌的关键通路李丁,加德·盖茨大卫··惠勒,伊莱恩··马迪斯,迈克尔··麦克莱伦,克里斯蒂安·齐布尔斯基斯卡丽·苏涅兹海蒂·格罗伊利希,唐娜··穆兹尼,玛格丽特··摩根,露辛达·富尔顿罗伯特··富尔顿, 张群元,迈克尔··温德尔,迈克尔··劳伦斯,大卫··拉尔森 ,陈肯,大卫··杜林,阿尼科·萨博,艾丽西亚··霍伊斯,沉华,沙利尼··贾贾尼,洛拉··刘易斯,奥蒂斯大厅,……理查德··威尔逊显示作者自然
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